Milk Thistle: Bueno para tu higado, malo para tus ganancias

El Cardo Mariano es un suplemento culturista muy popular y es actualmente la planta más profundamente  investigada para el tratamiento de enfermedades hepáticas (con más de 450 trabajos publicados ). La silimarina, es un extracto flavonoide de cardo de leche, y se ha utilizado clínicamente para el tratamiento de enfermedades hepáticas alcohólicas en Europa y Asia durante casi 2.000 años. En la actualidad esta sustancia es utilizada por los culturistas como medida de protección para el hígado cuando se utilizan altas dosis de esteroides orales.

La Silymarina no es soluble en agua y por lo general se administra como un extracto estandarizado encapsulado. La absorción por administración oral es más bien baja, con sólo un dos o tres por ciento. Los niveles máximos en plasma después de una dosis oral se consiguen a las cuatro / seis horas. La razón de este significativo estudio es debido a que el mecanismo descrito para el cardo de leche es que trabaja en la próstata. Se muestra eficacia en el tratamiento del cáncer de próstata, ya que evita que el receptor de andrógenos “trabaje” en el núcleo de la célula. Esto puede ser bueno si usted está luchando contra el cáncer de próstata, pero es malo si usted está tratando de obtener una célula del músculo para crecer . Para que la testosterona haga su funcion, tiene que pasar de la sangre al interior de la célula muscular , y unirse al receptor de andrógenos dentro de la célula, entonces viajar al interior del núcleo donde se une a tu DNA.Los cientificos fueron capaces de mostrar que el cardo mariano no redujo el número de receptores de andrógenos, ni evitar que los andrógenos (es decir, la testosterona) se uniera a los receptores. Lo único que parecía hacer era evitar que el receptor de andrógenos viajara al núcleo, y en nuestro caso, evitar el efecto deseado. El receptor de andrógenos, una vez unido al andrógeno, debe llegar hasta el núcleo con el fin de aumentar la sintesis proteíca . Asi que usa este producot si estas teniendo problemas de toxicidad hepática. Y usalo por unas pocas semanas . Hay otras hierbas con tremendos efectos hepatoprotectores, asi que quiza podrías darles una oportunidad.

Title:  Silymarin inhibits function of the androgen receptor by reducing nuclearlocalization of the receptor in the human prostate cancer cell line LNCaP.Authors: Zhu W, Zhang JS, Young CY.Source: Carcinogenesis 2001 Sep;22(9):1399-403

Research Summary
Agents with novel mechanisms of blocking androgen receptor (AR) function may be useful for prostate cancer prevention and therapy. Previous studies showed that silibinin (SB), the major active component of Milk Thistle, could inhibit cell proliferation of a human prostate cancer cell line by stopping the cell cycle without causing cell death. This study further demonstrates the potential molecular mechanism by which Milk Thistle acts on androgen-responsive prostate cancer cells by inhibiting function of the AR. We observed that Silymarin (SM) and SB inhibited androgen-stimulated cell proliferation as well as androgen-stimulated secretion of both prostate-specific antigen (PSA) and human glandular kallikrein (hK2).Additionally, for the first time, we show that SM and SB diminished transactivation activity of the AR. However, SM did not affect AR levels and steroid-binding ability of total AR in western blotting and ligand-binding assays. Intriguingly, we found that nuclear AR levels are significantly reduced by SM and SB in the presence of androgens. This study provides a new insight into how Milk Thistle negatively modulates androgen action in prostate cancer cells.

Discussion

Milk Thistle is a popular bodybuilding supplement and is currently the most well researched plant for the treatment of liver disease (with over 450 published peer review papers). Silymarin, a flavonoid extract from Milk Thistle, has been used clinically for alcoholic liver disease treatment in Europe and Asia for almost 2,000 years. Currently it?s used by bodybuilders as a protective measure for the liver when using high doses of orals.Silymarin is not water soluble and is typically administered as an encapsulated standardized extract. The absorption with oral administration is rather low, with only two to three percent being effectively taken up. The peak plasma levels after an oral dose are achieved in four to six hours. The reason this study is significant is because of the described mechanism that Milk Thistle is working in the prostate. It is showing effectiveness in treating prostate cancer because it prevents the androgen receptor from making it to the nucleus of the cell. This may be good if you are fighting cancer of the prostate, but it is bad if you are trying to get a muscle cell to grow larger.In order for testosterone to work, it must pass from the blood to the inside of a muscle cell, bind to the androgen receptor inside the cell, then travel inside the nucleus where it binds to your DNA.These researchers were able to show that Milk Thistle did not reduce the number of androgen receptors, nor did it prevent androgens (i.e., testosterone) from binding to the receptors. All it seemed to do was prevent the androgen receptor from traveling to the nucleus, and in our case, this prevents the desired effect. The androgen receptor, once bound to the androgen, must make it to the nucleus in order to increase protein synthesis.Bottom line: Use Milk Thistle if you are sure you are having liver toxicity problems. Then, only use it for a few weeks at a time. There are other herbs with tremendous hepatoprotective effects, so you might give them a try instead.

http://www.ncbi.nlm.nih.gov/pubmed/11532861

Adaptacion y traduccion realizada por Trukis

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